|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
|
21460840 |
2011 |
|
rs4147929
|
|
Alzheimer's Disease
|
A |
0.860 |
GeneticVariation
|
GWASDB |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
24162737 |
2013 |
|
rs3752246
|
|
Alzheimer's Disease
|
G |
0.850 |
GeneticVariation
|
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
rs115550680
|
|
Alzheimer's Disease
|
G |
0.830 |
GeneticVariation
|
GWASDB |
Genome-wide significance in fully adjusted models (sex, age, APOE genotype, population stratification) was observed for a SNP in ABCA7 (rs115550680, allele = G; frequency, 0.09 cases and 0.06 controls; odds ratio [OR], 1.79 [95% CI, 1.47-2.12]; P = 2.2 × 10(-9)), which is in linkage disequilibrium with SNPs previously associated with Alzheimer disease in Europeans (0.8 < D' < 0.9).
|
23571587 |
2013 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.
|
21460840 |
2011 |
|
rs4147929
|
|
Alzheimer's Disease
|
A |
0.860 |
GeneticVariation
|
GWASCAT |
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
|
24162737 |
2013 |
|
rs4147929
|
|
Alzheimer's Disease
|
A |
0.860 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs4147929
|
|
Alzheimer's Disease
|
|
0.860 |
GeneticVariation
|
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs4147929
|
|
Alzheimer's Disease
|
|
0.860 |
GeneticVariation
|
GWASCAT |
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.
|
31473137 |
2019 |
|
rs3752246
|
|
Alzheimer's Disease
|
G |
0.850 |
GeneticVariation
|
GWASCAT |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
rs115550680
|
|
Alzheimer's Disease
|
G |
0.830 |
GeneticVariation
|
GWASCAT |
Genome-wide significance in fully adjusted models (sex, age, APOE genotype, population stratification) was observed for a SNP in ABCA7 (rs115550680, allele = G; frequency, 0.09 cases and 0.06 controls; odds ratio [OR], 1.79 [95% CI, 1.47-2.12]; P = 2.2 × 10(-9)), which is in linkage disequilibrium with SNPs previously associated with Alzheimer disease in Europeans (0.8 < D' < 0.9).
|
23571587 |
2013 |
|
rs3795065
|
|
Alzheimer's Disease
|
|
0.700 |
GeneticVariation
|
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs3752241
|
|
Alzheimer's Disease
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs3752231
|
|
Alzheimer's Disease
|
|
0.700 |
GeneticVariation
|
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs111278892
|
|
Alzheimer's Disease
|
G |
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The associations of rs3764650 with CSF Aβ<sub>1-42</sub>, t-tau and p-tau were analyzed in non-dementia AD, including preclinical and prodromal AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
|
30596067 |
2018 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
An intronic low-frequency variant rs78117248 (minor allele frequency 3·8% in 58 patients with Alzheimer's disease and in controls 1·8% in 28 controls) showed strongest association with Alzheimer's disease (odds ratio 2·07, 95% CI 1·31-3·27; p=0·0016), and remained significant after conditioning for the GWAS top single nucleotide polymorphisms rs3764650, rs4147929, and rs3752246 (2·00, 1·22-3·26; p=0·006).
|
26141617 |
2015 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
After adjustment of age, sex, and APOE ε4 allele, rs3764650 remained to be an independent predictor of AD (p = 0.001).
|
24908168 |
2014 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
ABCA7 rs3764650 polymorphism was significantly associated with A</span>D risk (OR=1.21, 95% CI 1.16-1.26, P<0.00001; I2=5%).
|
29441941 |
2017 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A comprehensive literature search for studies involving the association between gene polymorphisms and AD was performed, and we finally selected 3 genes (4 polymorphisms) for the meta-analysis: ABCA7 (rs3764650), CD33 (rs3865444), and TOMM40 (rs157580, rs2075650).
|
26795201 |
2016 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Three common loci were confirmed to increase the risk of AD (rs3764650: OR = 1.20, 95% CI = 1.16-1.24; rs3752246: OR = 1.13,95% CI = 1.08-1.19; rs4147929: OR = 1.17, 95% CI = 1.10-1.24), but the associations varied among the different races.
|
29782324 |
2018 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We observed a significant association between rs3764650 and AD using the allele (P = 1.76E - 26, odds ratio (OR) = 1.21, 95 % confidence interval (CI) 1.17-1.26), dominant (P = 4.00E - 04, OR = 1.17, 95 % CI 1.07-1.28), recessive (P = 3.00E - 03, OR = 1.43, 95 % CI 1.13-1.81), and additive models (P = 3.00E - 03, OR = 1.49, 95 % CI 1.16-1.91).
|
24643655 |
2014 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Thus, in African Americans the interactive effects of ABCA7 rs3764650 and aerobic fitness likely compound overall ABCA7-related AD risk, and may contribute to health disparities whereby African Americans are at a higher risk for dementia, with double the prevalence of AD.
|
31024289 |
2019 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Besides the previously reported APOE and CR1 loci, we found that the ABCA7 (rs3764650; P = .02) and CD2AP (rs9349407; P = .03) AD susceptibility loci are associated with neuritic plaque burden.
|
23836404 |
2013 |
|
rs3764650
|
|
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5.0 × 10(-21)) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10(-14); including ADGC data, meta P = 1.2 × 10(-16)) are new Alzheimer's disease susceptibility loci.
|
21460840 |
2011 |